A PHYSIOLOGICALLY BASED PHARMACOKINETIC FRAMEWORK FOR QUANTIFYING ANTIBODY DISTRIBUTION GRADIENTS FROM TUMORS TO TUMOR-DRAINING LYMPH NODES

A Physiologically Based Pharmacokinetic Framework for Quantifying Antibody Distribution Gradients from Tumors to Tumor-Draining Lymph Nodes

Immune checkpoint blockades prescribed in the neoadjuvant setting are now under active investigation for many types of tumors, and many have GINGER shown early success.The primary tumor (PT) and tumor-draining lymph node (TDLN) immune factors, along with adequate therapeutic antibody distributions to the PT and TDLN, are critical for optimal immune

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Francisella tularensis PCR detection in Cape hares (Lepus capensis) and wild rabbits (Oryctolagus cuniculus) in Algeria

Abstract Tularemia is a zoonosis caused by the bacterium Francisella tularensis.Leporids are primary sources of human infections in the northern hemisphere.Africa is classically considered free of tularemia, but recent data indicate that this dogma might BUBBLE BATH be wrong.We assessed the presence of this disease in wild leporids in Algeria.Betwe

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Support practices by an interdisciplinary team in a palliative-care unit for relatives of patients in agonal phase

Abstract Background In the absence of extant recommendations, the aim of this study was to formalise support practices used by an interdisciplinary team in a palliative-care unit (PCU) for the relatives of patients in the agonal phase preceding death.The secondary objective was to understand the expectations of relatives during this phase in terms

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